Fisetin is a natural plant flavonoid with powerful antioxidant properties that supports memory and cognitive function. Scientific research shows that this phytochemical may contribute to slowing down the aging process thanks to its senolytic properties.
Description and main properties of fisetin
The plant flavonoid fisetin is found in small amounts in many fruits, vegetables and other plants, where it functions as a yellow coloring agent. It also plays a similar role in the common sumac (cotinus coggygria), from whose stems the Double Wood dietary supplement is extracted.
Like other polyphenols, such as resveratrol, fisetin acts as an activator of sirtuins, thereby helping to increase lifespan. Numerous laboratory studies have shown that this flavonoid counteracts various types of cancer by contributing to the induction of apoptosis of cancer cells and reducing their resistance to this programmed cell death.
Fisetin also has strong senolytic (aging-slowing) properties. By promoting the self-destruction of aging and diseased cells in the body, it reduces markers of biological aging in the body and helps limit age-related pathological changes. Laboratory studies of umbilical cord endothelial cell cultures have shown that fisetin induces their apoptosis by inhibiting the anti-apoptotic protein Bcl-xL. Clinical studies have shown that its senolytic potential exceeds twice that of quercetin.
In addition, fisetin has the ability to inhibit the action of a number of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin 6, and the transcription factor NF-κB.
Benefits of taking fisetin
Contributes to improving memory and cognitive functions – A number of scientific studies have shown that fisetin stimulates the growth of brain cells and contributes to improving memory. The flavonoid has the ability to cross the blood-brain barrier and stimulate intercellular communication in the hypothalamus – a part of the brain associated with long-term memory.
Helps slow down aging - The senolytic properties of fisetin are mainly due to its ability to inhibit the accumulation of age-damaged cells and stimulate their programmed death. These cells, which accumulate throughout the body, increase the body's susceptibility to inflammatory processes and suppress immune function. They secrete various substances - inflammatory molecules such as cytokines and chemokines, matrix metalloproteinases that cause pathological changes, and growth factors that accelerate aging processes. A study of the senolytic properties of 10 different flavonoids, published in the prestigious British medical journal The Lancet, categorically ranks fisetin in first place, with a significant lead over curcumin, quercetin, and resveratrol.
Exhibits powerful antioxidant properties – Fisetin powerfully counteracts active oxygen species that damage important structures in the body - cell membranes, lipids, amino acids, carbohydrates and even nucleic acids and DNA. Thus, free radicals trigger an inflammatory response, which in most cases involves not only the affected areas, but also the healthy tissues around them.
Supports Heart Health – Scientific analysis shows that fisetin helps stimulate cardiovascular regeneration by activating genes involved in cell proliferation. According to scientists, this may contribute to preventing ischemic damage in the event of a heart attack.
Studying the effects of fisetin on the human body has revealed other beneficial properties. The flavonoid helps relieve symptoms of anxiety and depression, contributes to controlling blood sugar and cholesterol, supports liver protection and therapies for various types of cancer.
Dosage and administration
Application: Antioxidant. Contributes to the protection of cells from oxidative stress.
Note: Not to be used by pregnant or lactating women, as well as by persons under 18 years of age. Not to be used as a substitute for a varied and nutritious diet. Do not exceed the recommended daily dose.
Recommended daily dose of the product: 1 capsule daily, preferably on an empty stomach.
Storage: In a cool, dry place, out of reach of children, away from direct sunlight!
Expiration and batch: Marked on the packaging.
